(Modeling proteins) (Chymotrypsin Mechanism: Step 1, Step 2, Step 3, Step 4, Step 5, Step 6)

Transition state between Steps 5 and 6 of Chymotrypsin Mechanism:
Ser195 is re-formed, and the acid group on the product is generated.

  (PDB file) (ARC file)

The final step in the chymotrypsin mechanism. The Trp252 - Ser195 ester-like bond splits, forming neutral Ser195 and Trp252 with a carboxylate ion at the C terminus. Because of the high activation barrier, this step is unlikely to occur. Toggle display all Toggle center picture Fit to screen Interesting parts: His57 Gly193 Asp194 Ser195 Trp252 Thr253 H2O Toggle spin Toggle stereo