(Modeling proteins) (Chymotrypsin Mechanism: Step 1, Step 2, Step 3, Step 4, Step 5, Step 6)
In this reaction, the proton on His57 should migrate to the peptide nitrogen of Thr253 and the peptide bond between Trp252 and Thr253 should break. Instead, as with the Step 2 - Step 4 reaction, the lowest barrier involves going backwards to the Step_1_2_Transition_state. Toggle display all Toggle center picture Fit to screen Interesting parts:
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