(Modeling proteins) (Chymotrypsin Mechanism: Step 1, Step 2, Step 3, Step 4, Step 5, Step 6)
In this reaction, a water molecule adds to the ester carbon of Trp252. A proton migrates to Thr253 to form an ammine ion. The transition state is almost certainly wrong, and by inference the reaction Step 4 → Step 5 is also wrong. Toggle display all Toggle center picture Fit to screen Interesting parts:
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