(Modeling proteins) (Chymotrypsin Mechanism: Step 1, Step 2, Step 3, Step 4, Step 5, Step 6)

Transition state between Steps 1 and 3 of Chymotrypsin Mechanism:
Serine 195 oxygen forms a covalent bond with substrate peptide carbon
Serine 195 hydroxyl hydrogen forms a covalent bond with substrate peptide nitrogen

  (PDB file) (ARC file)

This transition state is higher in energy than either of the transition states for Steps 1 and 2 or Steps 2 and 3, therefore the path from Step 1 to Step 3 is not the lowest energy path.   Toggle display all Toggle center picture Fit to screen Interesting parts: His57 Gly193 Asp194 Ser195 Trp252 Thr253 H2O Toggle spin Toggle stereo