(Modeling proteins) (Chymotrypsin Mechanism: Step 1, Step 2, Step 3, Step 4, Step 5, Step 6)

Transition state between Steps 4 and 5 of Chymotrypsin Mechanism

  (PDB file) (ARC file)

In this reaction, a water molecule adds to the ester carbon of Trp252. A proton migrates to Thr253 to form an ammine ion. The transition state is almost certainly wrong, and by inference the reaction Step 4 → Step 5 is also wrong. Toggle display all Toggle center picture Fit to screen Interesting parts: His57 Gly193 Asp194 Ser195 Trp252 Thr253 H2O Toggle spin Toggle stereo